منابع مشابه
Small Molecule Bax Agonists for Cancer Therapy
Bax, a central death regulator, is required at the decisional stage of apoptosis. We recently identified serine 184 (S184) of Bax as a critical functional switch controlling its proapoptotic activity. Here we used the structural pocket around S184 as a docking site to screen the NCI library of small molecules using the UCSF-DOCK programme suite. Three compounds, small-molecule Bax agonists SMBA...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2015
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2015.03.016